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Muscle Building Supplements

Muscle Building Supplements -  BullWorker's 247BodyBuilder is the ultimate  natural muscle building supplement which stimulates and enhances your body's natural GH growth hormone levels resulting in bigger, stronger more powerful muscles with lower levels of body fat. Muscle building is not the overly complex process that many claim it to be. Train hard with maximum intensity then allow your body to recover and grow. There are many different ways to do this - but the key is intensity. to GREATLY ENHANCE the process take 247BodyBuilder capsules and your muscle grow and strength will go into overdrive. This is why 247BodyBuilder is the No.1 physique enhancing muscle building sports nutritional supplement. Providing the most highly naturally anabolic branched chain amino acid complex in a full strength capsule making it the No.1 choice for anyone who is serious about adding EXTREME MUSCLE SIZE & POWER FAST.

247Bodybuilder increases both natural growth hormone and insulin levels, thereby increasing anabolism and anti-catabolism. It also prevents a decrease in post-workout Testosterone levels, and raises levels after exercise. In addition it decreases body fat , especially visceral fat, the fat that accumulates inside the abdomen.

What all of this means is that if you are serious about developing the BEST PHYSIQUE that you can with bigger, stronger muscles and less body fat then this is the "must have" supplement for you.

BullWorker's 247BodyBuilder is an enhanced, advanced anabolic formula designed for all serious weight lifters, Rugby Player and bodybuilders looking to support increased strength and muscularity!

The latest scientific research has been used to formulate this amazing natural bodybuilding supplement with users reporting gains in muscle size and strength enhancement on a par with chemical supplementation. Utilising the potent amino acid leucine - the amazing natural anabolic supplement - 247BodyBuilder enhances protein synthesis and promotes a higher rate of muscle growth and repair via the mTOR anabolic pathway for peak muscle building.  247BodyBuilder utilizes an amazing naturally highly anabolic 4:1:1 branched chain amino acids ratio that contains four times the amount of the leucine to isoleucine and valine for powerful strength and muscle building, anti-catabolic muscle support, energy production and recovery.

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BETTER THAN WHEY PROTEIN  - Ingestion of a supplement containing the active ingredients in 247Bodybuilder while following an 8-week resistance training program resulted in a greater decrease in percent body fat, an increase in lean muscle size, and 10-RM strength gains on the bench press and squat vs. ingestion of a whey supplement or a sports drink. In addition, the ingestion of a whey protein supplement resulted in greater lean mass gains than ingestion of a sports drink.* (Jim Stoppani, et al., Journal of the International Society of Sports Nutrition, 2009.) After exercise, recovery of muscle protein synthesis benefits from BCAA's to increase tissue levels of leucine in order to release the inhibition of the initiation factor 4 complex through the activation of the protein kinase mammalian target of rapamycin (mTOR).* Leucine's effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake.* (Layne Norton and Donald Layman, Journal of Nutrition, 2006.)

Exercise may increase BCAA requirement, and BCAA supplementation before exercise may reduce the breakdown of muscle proteins during exercise. Leucine boosts protein synthesis in skeletal muscle, meaning that 247Bodybuilder capsules reduce muscle damage induced by exercise and promote recovery from the damage. Findings also suggest that BCAA's may be useful for muscle recovery following intense exercise, as BCAA supplementation before training decreased delayed-onset muscle soreness after squatting exercise. (Yoshiharu Shimomura, et al., Journal of Nutrition, 2006.)

Supplementation with BCAA's was suggested to increase the lactate threshold before exhaustion in high-intensity exercise on a cycle ergometer. Subjects using BCAA's had noticeably higher plasma BCAA concentrations than the non-supplemented group, in addition to higher respiratory exchange ratio and both VO2 max and VO2 workload levels. These results suggest that BCAA supplementation may be effective to increase endurance exercise capacity. (Keitaro Matsumoto, et al., Journal of Nutritional Science Vitaminol, 2009.)

Exercise is known to deplete serum BCAA levels via oxidation. BCAA supplementation before and after intense exercise has been suggested to exhibit beneficial effects for decreasing exercise-induced muscle damage and promoting muscle protein synthesis. This suggests that BCAA's are a useful supplement in relation to exercise and sports. (Yoshiharu Shimomura, et al., Journal of Nutrition, 2004.)

Studies suggest that supplementation with leucine can both acutely and over a longer period of time beneficially affect muscle protein anabolism. In elderly adults, even small amounts of ingested leucine may acutely improve muscle protein retention. The anabolic effect of extra leucine on muscle protein was observed in the elderly and the response of muscle protein synthesis following ingestion of small amounts of amino acids was surmised to be greatly enhanced by additional leucine supplementation. (Christos Katsanos, et al., American Journal of Physiological and Endocrinological Metabolism, 2006.)

247Bodybuilder is a high potency BCAA 4:1:1 supplement. Each bottle contains 180 capsules. Each dosage is 4 capsules providing 2,000mg Leucine , 500mg Isoleucine and 500mg Valine. BUY ONE BOTTLE GET ANOTHER BOTTLE FREE.

In skeletal muscles and the heart, BCAA supplementation alone, has the same benefits of stimulating protein synthesis and reducing muscle breakdown, as is the case when the supply of all amino acids is increased (May and Buse, 1989). BCAAs supplementation has been demonstrated to preserve and even increase muscle size under extreme physical conditions where there would normally be a net loss of muscle tissue (Schena et al., 1992; Bigard et al., 1996). Research looking at the effect of BCAA supplementation during prolonged skiing at altitude, found that the consumption of BCAAs helped to prevent a loss of body mass (Bigard et al., 1996). Research has also demonstrated a positive effect on immune function with BCAAs supplementation (Bassit et al., 2000; Bassit et al., 2002).

During aerobic exercise, or any prolonged exercise session, BCAAs can be oxidized within the mitochondria of skeletal muscles to produce aerobic energy – the six other essential amino acids are mainly catabolized within the liver (Shimomura et al., 2004). It is well known that during aerobic exercise – endurance exercise in particular – the level of BCAAs metabolised to produce energy increases significantly (Rennie, 1996; Kobayashi et al., 1999). Therefore, during any prolonged period of exercise, a significant amount of BCAAs, may be metabolised and may lead to a depletion of BCAAs within muscles.

It should also be noted that Zinc, Magnesium, and Vitamin B6 all have positive effects on mood and may help to alleviate the low feeling sometimes experienced during heavy training.

Research looking at the effect of BCAA supplementation has found that taking 77mg of BCAAs, per kg of bodyweight, before exercise results in a significant reduction in the amount of muscle breakdown (MacLean et al., 1994). So to reduce muscle breakdown during exercise a 70kg athlete would consume around 5g of BCAAs. It has also been demonstrated that the consumption of BCAAs before and after exercise reduces the levels of serum creatine kinase activity – which indicates reduced levels of muscle breakdown (Coombes and McNaughton, 2000; Nosaka, 2003). BCAA supplementation before and after exercise also appears to increase the recovery rate from exercise, as indicated by a reduction in muscle soreness following exercise (Nosaka, 2003). Therefore, BCAA supplementation, before and after exercise, appears to be beneficial for reducing the level of exercise-induces muscle damage and for increasing muscle protein synthesis (muscle building) and enhancing the recovery process following exercise.

A further benefit, is the positive effects that BCAAs supplementation appears to have on endurance performance. BCAAs compete with the amino acid trytophan for uptake into the brain. During prolonged exercise BCAAs are used for fuel and this leads to a decreased level of BCAAs in the blood. The decreased levels of BCAAs in the blood means there is a greater ratio of tryptophan uptake into the brain. High levels of tryptophan in the brain, are associated with increased feelings of tiredness and fatigue, and hence, reduced exercise performance. Supplementation with BCAAs during exercise keeps the levels of BCAAs elevated in the blood and helps to delay the build up of tryptophan in the brain. Research suggests that supplementing with BCAAs during exercise may have a positive effect on exercise performance by reducing fatigue (Blomstrand et al., 1991).

BCAA Benefits – The Studies

A study evaluated the efficacy of a BCAA supplement in comparison to a whey supplement or carbohydrate drink during eight-week resistance training. At random, thirty-six strength trained males either received 28 grams of whey protein or 14 grams of BCAAs or 28 grams of carbohydrates in an energy drink during the workout. Body mass, body fat percentage and 10 RM on the barbell bench press and barbell squat were tested before and after the eight-week program. Statistical analysis of recorded data clearly established that consumption of BCAA supplement during workouts led to a greater increase in lean muscle mass, fat loss and 10RM strength on the barbell bench press and barbell squat than whey or carbohydrate supplement. This study proved that the BCAA powder benefits users by promoting fat loss, promoting muscle growth, preventing fatigue, and maintaining strength. A significant benefit associated with the intake of branched chain amino acids is the decrease in muscle soreness after exercise. This means that BCAA supplementation results in faster recovery from exercise-induced protein damage and gives an athlete the opportunity to train harder.
BCAA Benefits – Lose Bodyfat

BCAA supplements benefit loss of visceral body fat that is present in deeper layers of body and hard to shed. The body as an indication of excessive muscle breakdown senses the higher BCAA levels during exercise. As a result, it stops muscle disruption and starts using more fat as the energy source. Moreover, BCAA increases insulin in the blood that it is utilized directly in muscles. In a study, twenty-five wrestlers were divided into three diet groups: high BCAA diet, low BCAA diet and control diet. They received the respective diets for 19 days. It was found that, on average, high BCAA diet group lost 17.3% body fat in the abdomen region. Thus, proper BCAA nutrition can be effective in targeted fat loss. In another study, one group of climbers was given BCAA supplements, while another group did not receive the supplement. Body fat was reduced in both groups. However, there was loss of muscle mass in those who did not receive BCAA supplements. Therefore, BCAAs benefits include fat loss while increasing the lean muscle mass.

BCAA Benefits – Increase Endurance and Reduce Fatigue

For endurance athletes who are involved in exercises for more than 3hr., BCAA supplements can help delay central fatigue and maintain mental activity. Central fatigue can severely affect the physical performance. A noted reason for central fatigue is increased level of 5-hydroxytryptamine (5-HT) in the brain. 5-HT is produced from an amino acid, tryptophan, and this synthesis depends upon the analogous concentration of tryptophan in the blood and the brain. If tryptophan crosses the blood-brain barrier, and the concentration is greater in the brain, there will be greater production of 5-HT, and thus, greater fatigue. BCAAs play a role in reducing fatigue by competing with tryptophan in crossing the blood-brain barrier. When BCAA are taken during exercise, the blood level of BCCA increases, thereby reducing tryptophan uptake in the brain as BCAA and tryptophan share the same carrier system. This diminishes exercise associated fatigue. During a 30-km cross-country race and a standardized cycle ergometer exercise, people who were given BCAA showed less exertion and mental fatigue and performed well at different cognitive tests after the activity.
BCAA Benefits – Immune System Health

Along with other benefits, BCAA supplements benefits include a stronger immune system. After an illness, the body is too weak to resume physical training and high volume exercise increases risk of infections and further immune suppression. BCAAs augment the glutamine loss and prevent a catabolic state by helping overcome damaging effects of exercise. Benefits of branched chain amino acids extend to reducing inflammation and strengthening immune system functioning after vigorous workouts.

References:

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2.Matthews DE. Observations of branched-chain amino acid administration in humans. J Nutr. 2005;135:1580S-4S.
3.Anthony JC, Reiter AK, Anthony TG, et al. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation.. 2002;51(4):928-936.
4.Bianchi G, Marzocchi R, Agostini F, Marchesini G. Update on nutritional supplementation with branched-chain amino acids. . 2005;8(1):83-87.
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6. Kraemer WJ, Ratamess NA, Volek JS, Hakkinen K, Rubin MR, French DN, Gomez AL, et al. The effects of amino acid supplementation on hormonal responses to resistance training overreaching. Metabolism. 2006 Mar;55(3):282-91.
7. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, Zhang XJ, Wolfe RR. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol. 2006 Feb;41(2):215-9. Epub 2005 Nov 23.
8. Morifuji M, Sakai K, Sanbongi C, Sugiura K. Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats. Br J Nutr. 2005 Apr;93(4):439-45.
9. Shimomura Y, Yamamoto Y, Bajotto G, Sato J, Murakami T, Shimomura N, Kobayashi H, Mawatari K. Nutraceutical effects of branched-chain amino acids on skeletal muscle. J Nutr. 2006 Feb;136(2):529S-32S.
10. Krieger JW, Sitren HS, Daniels MJ, Langkamp-Henken B. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression. Am J Clin Nutr. 2006 Feb;83(2):260 -74.
11.Bassit, R. A., Sawada, L. A., Bacurau, R. F. P., Navarro, F. and Costa Rosa, L. F. B. P. (2000) The effect of BCAA supplementation upon the immune system of triathletes. Medicine and Science in Sports and Exercise. 32, 1214-1219.
12.Bassit, R. A., Sawada, L. A., Bacurau, R. F., Navarro, F., Martins, E. Jr, Santos, R. V., Caperuto, E. C., Rogeri, P. and Costa Rosa, L. F. (2002) Branched-chain amino acid supplementation and the immune response of long-distance athletes. Nutrition. 18 (5), 376-379.
13.Bigard, A. X., Lavier, P., Ulmann, L., Legrand, H., Douce, P. and Guezennec, C. Y. (1996) Branched-chain amino acid supplementation during repeated prolonged skiing exercises at altitude. Int J Sport Nutr. 6 (3), 295-306.
14.Blomstrand, E., Hassmen, P. and Ekblom, B. (1991) Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. European Journal of Applied Physiology. 63, 83-88.
15.Coombes, J. S. and McNaughton, L. R. (2000) Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness. 40, 240-246.
16.Kobayashi, r. shimomura, Y., Murakami, T., Nakai, N., Otsuka, M., Arakawa, N., Shimizu, K. and Harris, R. A. (1999) Hepatic branched-chain alpha-keto acid dehydrogenase complex in female rats: activation by exercise and starvation. J Nutr Sci. Vitaminol. 45, 303-309.
17.May, M. E. and Buse, M. G. (1989) Effects of branched chain amino acids on protein turnover. Diab Metab Rev. 5 (3), 227-245.
18.MacLean, D. A., Graham, T. E. and Saltin, B. (1994) Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol. 267, E1010-E1022.
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20.Rennie, M. J. (1996) Influence of exercise on protein and amino acid metabolism. In: Handbook of Physiology, Sect 12: Exercise: Regulation and Integration of Multiple Systems (Rowell, L. B. & Shepherd, J. T., eds), Chapter 22. 995-1035. American Physiological Society, Bethesda, MD.
21.chena, F., Guerrini, F. and Tregnaghi, P. (1992) Branched-chain amino acid supplementation during trekking at altitude. The effects on loss of body mass, body composition, and muscle power. European Journal of Applied physiology. 65, 394-398.
22.Shimomura, Y., Murakami, T., Nakai, N., Nagasaki, M. and Harris, R. A. (2004) Exercise Promotes BCAA Catabolism: Effects of BCAA Supplementation on Skeletal Muscle during Exercise. J Nutr. 134, 1583S-1587S.